Update on genetics in inflammatory disease

被引：31

作者：

Noomen, Casper G.

Hommes, Daniel W. ^{[1
]}

Fidder, Herma H. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Gastroenterol & Hepatol, Leiden, Netherlands

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2009年 / 23卷 / 02期

关键词：

Crohn's disease; ulcerative colitis; genes; HLA and tumour necrosis factor-alpha; NOD2; NOD1; Toll-like receptors; MDR1; DLG5; IL23R; ATG16L1; GENOME-WIDE ASSOCIATION; CATION TRANSPORTER GENES; DLG5 R30Q VARIANT; CROHNS-DISEASE; BOWEL-DISEASE; SUSCEPTIBILITY LOCI; MDR1; GENE; ULCERATIVE-COLITIS; NOD2; MULTIDRUG-RESISTANCE-1;

D O I：

10.1016/j.bpg.2009.02.005

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Crohn's disease and ulcerative colitis are chronic inflammatory disorders caused by a disruptive interaction between the immune system and gut luminal factors. Although the exact aetiology of MID remains unclear, accumulating data, including genome-wide association studies (GWAS), have advanced our understanding of the immunopathogenesis. This review highlights the role in gut homeostasis and IBD pathogenesis. It focuses on past and recent advances in our understanding of IBD, including genetics and immunobiology. Recently published GWAS have confirmed earlier findings related to the NOD2 gene and the IBD5 locus. In addition, over 30 novel loci have been identified. Several promising associations between Crohn's disease and gene variants have been identified and replicated, the two most widely replicated being variants in the IL23R and ATG16L1 genes. These findings highlight and further support the importance of the immune system and its interactions with the intestinal flora in the pathogenesis of inflammatory bowel disease. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：233 / 243

页数：11

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