The aging immune system: Primer and prospectus

被引：911

作者：

Miller, RA ^{[1
]}

机构：

[1] DEPT VET AFFAIRS MED CTR, ANN ARBOR, MI 48109 USA

来源：

SCIENCE | 1996年 / 273卷 / 5271期

关键词：

D O I：

10.1126/science.273.5271.70

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Changes in T lymphocyte populations underlie much of the age related decline in the protective immune response. Aging leads to the replacement of virgin T cells by memory T cells and to the accumuiation of cells with signal transduction defects. Studies of antibody gene assembly, accessory cell function, post-thymic T cell development, skewed selection of T cell receptor repertoire, and the clinical concomitants of immune senescence will shed new light on the causes and consequences of age-dependent immune failure.

引用

页码：70 / 74

页数：5

共 77 条

[1]

ALBRIGHT JW, 1990, J IMMUNOL, V144, P3970

[2]

AGE-ASSOCIATED IMPAIRMENT OF MURINE NATURAL-KILLER ACTIVITY [J].