Characterization of mocarhagin, a cobra venom metalloproteinase from Naja mocambique mocambique, and related proteins from other elapidae venoms

被引：30

作者：

Ward, CM ^{[1
]}

Vinogradov, DV ^{[1
]}

Andrews, RK ^{[1
]}

Berndt, MC ^{[1
]}

机构：

[1] BAKER MED RES INST,HAZEL & PIP APPEL VASC BIOL LAB,PRAHRAN,VIC 3181,AUSTRALIA

来源：

TOXICON | 1996年 / 34卷 / 10期

关键词：

D O I：

10.1016/0041-0101(96)00115-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mocarhagin, a cobra venom metalloproteinase from Naja mocambique mocambique, has previously been shown to cleave selectively two mucin-like substrates on platelets and neutrophils within anionic amino acid sequences containing sulfated tyrosines, We now show that purified mocarhagin has haemagglutinin activity, and a similar profile for inhibition of mocarhagin-dependent haemagglutination and proteolysis suggests that the lectin-like domain may account for its substrate specificity, In addition, immunologically and functionally related proteins were detected in other Elapidae venoms. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1203 / 1206

页数：4

共 10 条

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