Membrane protein complexes

被引:25
作者
Byrne, B [1 ]
Iwata, S
机构
[1] Univ London Imperial Coll Sci Technol & Med, Dept Biol Sci, London SW7 2AZ, England
[2] Univ London Imperial Coll Sci Technol & Med, Div Biomed Sci, London SW7 2AZ, England
关键词
D O I
10.1016/S0959-440X(02)00316-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A wide range of membrane protein structures have been published during the past two years. These have included proteins from both eucaryotic and heterologously overexpressed sources. Whereas some of these proteins were crystallised using conventional techniques, others employed the new methods of lipidic cubic phase crystallisation and antibody fragment co-crystallisation. These and other new approaches to the expression and crystallisation of membrane proteins are accelerating structural studies of membrane protein complexes.
引用
收藏
页码:239 / 243
页数:5
相关论文
共 35 条
[1]  
Abramson J, 2000, NAT STRUCT BIOL, V7, P910
[2]   Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors [J].
Brejc, K ;
van Dijk, WJ ;
Klaassen, RV ;
Schuurmans, M ;
van der Oost, J ;
Smit, AB ;
Sixma, TK .
NATURE, 2001, 411 (6835) :269-276
[3]   RETRACTED: Structure of MsbA from E-coli:: A homolog of the multidrug resistance ATP binding cassette (ABC) transporters (Retracted Article. See vol 314, pg 1875, 2006) [J].
Chang, G ;
Roth, CB .
SCIENCE, 2001, 293 (5536) :1793-1800
[4]   Crystallization in cubo:: general applicability to membrane proteins [J].
Chiu, ML ;
Nollert, P ;
Loewen, MC ;
Belrhali, H ;
Pebay-Peyroula, E ;
Rosenbusch, JP ;
Landau, EM .
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 2000, 56 :781-784
[5]   A refined structure of human aquaporin-1 [J].
de Groot, BL ;
Engel, A ;
Grubmüller, H .
FEBS LETTERS, 2001, 504 (03) :206-211
[6]   The structure of the potassium channel:: Molecular basis of K+ conduction and selectivity [J].
Doyle, DA ;
Cabral, JM ;
Pfuetzner, RA ;
Kuo, AL ;
Gulbis, JM ;
Cohen, SL ;
Chait, BT ;
MacKinnon, R .
SCIENCE, 1998, 280 (5360) :69-77
[7]   X-ray structure of a CIC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity [J].
Dutzler, R ;
Campbell, EB ;
Cadene, M ;
Chait, BT ;
MacKinnon, R .
NATURE, 2002, 415 (6869) :287-294
[8]   Structure of a glycerol-conducting channel and the basis for its selectivity [J].
Fu, DX ;
Libson, A ;
Miercke, LJW ;
Weitzman, C ;
Nollert, P ;
Krucinski, J ;
Stroud, RM .
SCIENCE, 2000, 290 (5491) :481-486
[9]   Structure at 2.3 Å resolution of the cytochrome bc1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment [J].
Hunte, C ;
Koepke, J ;
Lange, C ;
Rossmanith, T ;
Michel, H .
STRUCTURE, 2000, 8 (06) :669-684
[10]   Structure of the Escherichia coli fumarate reductase respiratory complex [J].
Iverson, TM ;
Luna-Chavez, C ;
Cecchini, G ;
Rees, DC .
SCIENCE, 1999, 284 (5422) :1961-1966