The use of experimental design in the optimization of risperidone biodegradable nanoparticles: in vitro and in vivo study

被引：16

作者：

Alzubaidi, Ali F. A. ^{[1
]}

El-Helw, Abdel-Raheem M. ^{[1
]}

Ahmed, Tarek A. ^{[1
,2
]}

Ahmed, Osama A. A. ^{[1
,3
]}

机构：

[1] King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut & Ind Pharm, POB 80200, Jeddah 1589, Saudi Arabia

[2] Al Azhar Univ, Dept Pharmaceut & Ind Pharm, Fac Pharm, Cairo, Egypt

[3] Menia Univ, Dept Pharmaceut & Ind Pharm, Fac Pharm, Al Minya, Egypt

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 02期

关键词：

Box-Behnken design; nanostructures; poly(lactic-co-glycolic acid); polycaprolactone; risperidone; SOLVENT EVAPORATION METHOD; DIFFUSION METHOD; RELEASE; POLYMERS; MATRICES; 9-HYDROXYRISPERIDONE; MICROSPHERES; ENHANCEMENT; FORMULATION; DELIVERY;

D O I：

10.3109/21691401.2016.1147453

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

The aim of this study was optimization of risperidone (model drug) biodegradable nanoparticles utilizing emulsion-solvent evaporation technique. Box-Behnken design was adopted to optimize the preparation process. Optimized nanoparticles were characterized for surface morphology using scanning electron microscope. Pharmacokinetic parameters were compared with the marketed tablets. Results revealed that the optimized formula showed 297.37 nm, 85.12%, and 59.79% for Y1, Y2, and Y3, respectively. Optimized formula showed significant improved bioavailability compared with marketed tablets. Successful achievement of prolonged risperidone release with improved bioavailability is expected to maximize patients' adherence to their antipsychotic drug therapy and to minimize risk of relapse during maintenance therapy.

引用

页码：313 / 320

页数：8

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