The many faces of p75NTR

被引：266

作者：

Hempstead, BL ^{[1
]}

机构：

[1] Cornell Univ, Weill Med Coll, Dept Med, New York, NY 10021 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2002年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0959-4388(02)00321-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neurotrophins utilize a complex receptor system consisting of Trk receptor tyrosine kinases and the structurally unrelated tumor necrosis factor receptor family member, p75(NTR), to confer diverse and sometimes opposing biological actions. The recent identification of selective ligands for p75(NTR), novel isoforms of this receptor, as well as new signaling partners, suggest that the numerous biological actions of the neurotrophins via p75(NTR) may reflect selectivity of ligand-receptor interactions and intracellular adaptor protein recruitment.

引用

页码：260 / 267

页数：8

共 69 条

[1] Upregulation of p75 neurotrophin receptor after stroke in mice does not contribute to differential vulnerability of striatal neurons [J].

Andsberg, G ;

Kokaia, Z ;

Lindvall, O .

EXPERIMENTAL NEUROLOGY, 2001, 169 (02) :351-363

[2] Signal transduction by tumor necrosis factor and its relatives [J].

Baud, V ;

Karin, M .

TRENDS IN CELL BIOLOGY, 2001, 11 (09) :372-377

[3]

Bentley CA, 2000, J NEUROSCI, V20, P7706

[4] Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR [J].

Bibel, M ;

Hoppe, E ;

Barde, YA .

EMBO JOURNAL, 1999, 18 (03) :616-622

[5] Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system [J].

Bibel, M ;

Barde, YA .

GENES & DEVELOPMENT, 2000, 14 (23) :2919-2937

[6] Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75NTR-dependent sphingolipid signaling pathways [J].

Bilderback, TR ;

Gazula, VR ;

Dobrowsky, RT .

JOURNAL OF NEUROCHEMISTRY, 2001, 76 (05) :1540-1551

[7] Nerve growth factor-induced p75-mediated death of cultured hippocampal neurons is age-dependent and transduced through ceramide generated by neutral sphingomyelinase [J].

Brann, AB ;

Tcherpakov, M ;

Williams, IM ;

Futerman, AH ;

Fainzilber, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (12) :9812-9818

[8] The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo [J].

Brennan, C ;

Rivas-Plata, K ;

Landis, SC .

NATURE NEUROSCIENCE, 1999, 2 (08) :699-705

[9] The zinc finger protein NRIF interacts with the neurotrophin receptor p75NTR and participates in programmed cell death [J].

Casademunt, E ;

Carter, BD ;

Benzel, I ;

Frade, JM ;

Dechant, G ;

Barde, YA .

EMBO JOURNAL, 1999, 18 (21) :6050-6061

[10] Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor [J].

Chittka, A ;

Chao, MV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (19) :10705-10710

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