The effects of rapid eye movement sleep deprivation and recovery on spatial reference memory of young rats

被引:37
作者
Li, Shenghui
Tian, Ying [2 ]
Ding, Yu [2 ]
Jin, Xinming
Yan, Chonghuai [3 ]
Shen, Xiaoming [1 ]
机构
[1] Shanghai Jiao Tong Univ, Xin Hua Hosp, Sch Med, Shanghai Key Lab Childrens Environm Hlth, Shanghai 200000, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Publ Hlth, Sch Med, Shanghai 200000, Peoples R China
[3] Shanghai Inst Pediat Res, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
MULTIPLE PLATFORM METHOD; LONG-TERM POTENTIATION; SLOW-WAVE SLEEP; PARADOXICAL SLEEP; REM-SLEEP; WATER-MAZE; SYNAPTIC PLASTICITY; THETA-RHYTHM; IN-VIVO; CONSOLIDATION;
D O I
10.3758/LB.37.3.246
中图分类号
B84 [心理学];
学科分类号
010107 [宗教学];
摘要
It is known that rapid eye movement (REM) sleep plays a crucial role in learning and memory Previous studies have demonstrated that postlearning REM sleep deprivation (RSD) impairs memory consolidation. Most of these studies observed only the effects of RSD on learning and memory. In the present study, we not only investigated the impacts of 48-h RSD on the spatial reference memory of young rats in a Morris water maze, but also specifically examined whether an REM rebound for 24-48 h after 48-h RSD affected the maintenance of spatial reference memory. RSD was induced by the modified multiple platform method, and spatial reference memory was tested in a Morris water maze. The results demonstrated that, compared with the control groups, posttraining RSD for 48 h produced a significant impairment in the retention of acquired spatial reference memory, and the impairment continuously existed after 24 and 48 h of release from sleep deprivation, which indicates that REM sleep plays a critical role in reference memory maintenance and consolidation. Moreover, postlearning RSD may lead to a long-term impairment in the consolidation of newly acquired memories.
引用
收藏
页码:246 / 253
页数:8
相关论文
共 40 条
[1]
Paradoxical sleep deprivation impairs acquisition, consolidation, and retrieval of a discriminative avoidance task in rats [J].
Alvarenga, Tathiana A. ;
Patti, Camilla L. ;
Andersen, Monica L. ;
Silva, Regina H. ;
Calzavara, Mariana B. ;
Lopez, Giorgia B. ;
Frussa-Filho, Roberto ;
Tufik, Sergio .
NEUROBIOLOGY OF LEARNING AND MEMORY, 2008, 90 (04) :624-632
[2]
Immediate as well as delayed post learning sleep but not wakefulness enhances declarative memory consolidation in children [J].
Backhaus, Jutta ;
Hoeckesfeld, Ralf ;
Born, Jan ;
Hohagen, Fritz ;
Junghanns, Klaus .
NEUROBIOLOGY OF LEARNING AND MEMORY, 2008, 89 (01) :76-80
[3]
Cellular and molecular connections between sleep and synaptic plasticity [J].
Benington, JH ;
Frank, MG .
PROGRESS IN NEUROBIOLOGY, 2003, 69 (02) :71-101
[4]
Sleep to remember [J].
Born, Jan ;
Rasch, Bjorn ;
Gais, Steffen .
NEUROSCIENTIST, 2006, 12 (05) :410-424
[5]
Corticohippocampal contributions to spatial and contextual learning [J].
Burwell, RD ;
Saddoris, MP ;
Bucci, DJ ;
Wiig, KA .
JOURNAL OF NEUROSCIENCE, 2004, 24 (15) :3826-3836
[6]
REM sleep deprivation attenuates actin-binding protein cortactin: A link between sleep and hippocampal plasticity [J].
Davis, CJ ;
Meighan, PC ;
Taishi, P ;
Krueger, JM ;
Harding, JW ;
Wright, JW .
NEUROSCIENCE LETTERS, 2006, 400 (03) :191-196
[7]
Sustained increase in hippocampal sharp-wave ripple activity during slow-wave sleep after learning [J].
Eschenko, Oxana ;
Ramadan, Wiam ;
Moelle, Matthias ;
Born, Jan ;
Sara, Susan J. .
LEARNING & MEMORY, 2008, 15 (04) :222-228
[8]
Rapid eye movement sleep deprivation selectively impairs recall of fear extinction in hippocampus-independent tasks in rats [J].
Fu, J. ;
Li, P. ;
Ouyang, X. ;
Gu, C. ;
Song, Z. ;
Gao, J. ;
Han, L. ;
Feng, S. ;
Tian, S. ;
Hu, B. .
NEUROSCIENCE, 2007, 144 (04) :1186-1192
[9]
Sleep and memory: a molecular perspective [J].
Graves, L ;
Pack, A ;
Abel, T .
TRENDS IN NEUROSCIENCES, 2001, 24 (04) :237-243
[10]
Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning [J].
Graves, LA ;
Heller, EA ;
Pack, AI ;
Abel, T .
LEARNING & MEMORY, 2003, 10 (03) :168-176