Proton transfers in the bacteriorhodopsin photocycle

被引：178

作者：

Lanyi, Janos K. ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92697 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2006年 / 1757卷 / 08期

关键词：

bacteriorhodopsin; retinal; X-ray structure; proton release; proton uptake; hydrogen-bonded chain;

D O I：

10.1016/j.bbabio.2005.11.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The steps in the mechanism of proton transport in bacteriorhodopsin include examples for most kinds of proton transfer reactions that might occur in a transmembrane pump: proton transfer via a bridging water molecule, coupled protonation/deprotonation of two buried groups separated by a considerable distance, long-range proton migration over a hydrogen-bonded aqueous chain, and capture as well as release of protons at the membrane-water interface. The conceptual and technical advantages of this system have allowed close examination of many of these model reactions, some at an atomic level. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：1012 / 1018

页数：7

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