Novel alternative for the N-S bond formation and its application to the synthesis of benzisothiazol-3-ones

被引：96

作者：

Correa, Arkaitz ^{[1
]}

Tellitu, Imanol ^{[1
]}

Dominguez, Esther ^{[1
]}

SanMartin, Raul ^{[1
]}

机构：

[1] Euskal Herriko Unibertsitatea, Fac Ciencia & Tecnol, Dept Quim Organ 2, Bilbao 48080, Spain

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 21期

关键词：

D O I：

10.1021/ol061867q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a series of benzisothiazolone derivatives starting from the readily available methyl thiosalicylate is presented. The key cyclization step features the formation of a N-acylnitrenium ion, generated by the hypervalent iodine reagent PIFA, and its succeeding intramolecular trapping by the thiole moiety leading to the construction of the title compounds by formation of a new N-S bond.

引用

页码：4811 / 4813

页数：3

共 31 条

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