Small silencing RNAs: an expanding universe

被引：1742

作者：

Ghildiyal, Megha

Zamore, Phillip D. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Worcester, MA 01605 USA

来源：

NATURE REVIEWS GENETICS | 2009年 / 10卷 / 02期

基金：

美国国家卫生研究院;

关键词：

PIWI-INTERACTING RNAS; DOUBLE-STRANDED-RNA; SMALL INTERFERING RNAS; DSRNA-BINDING-PROTEIN; TRANS-ACTING SIRNAS; GERM-LINE DEVELOPMENT; DROSOPHILA-MELANOGASTER; ENDOGENOUS SIRNAS; DNA METHYLATION; GENE-EXPRESSION;

D O I：

10.1038/nrg2504

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA classes have been identified, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). These classes differ in their biogenesis, their modes of target regulation and in the biological pathways they regulate. There is a growing realization that, despite their differences, these distinct small RNA pathways are interconnected, and that small RNA pathways compete and collaborate as they regulate genes and protect the genome from external and internal threats.

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收藏

页码：94 / 108

页数：15

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