Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study

被引：40

作者：

Lavrenkov, Konstantin ^{[1
,2
]}

Singh, Shalini ^{[2
,7
]}

Christian, Judith A. ^{[2
,8
]}

Partridge, Mike ^{[3
]}

Nioutsikou, Elena ^{[3
]}

Cook, Gary ^{[4
,5
]}

Bedford, James L. ^{[3
]}

Brada, Michael ^{[2
,6
]}

机构：

[1] Ben Gurion Univ Negev, Dept Oncol, Fac Hlth Sci, Soroka Univ Med Ctr, IL-84101 Beer Sheva, Israel

[2] Royal Marsden NHS Fdn Trust, Lung Res Unit, Surrey, England

[3] Royal Marsden NHS Fdn Trust, Joint Dept Phys, Surrey, England

[4] Royal Marsden NHS Fdn Trust, PET, Surrey, England

[5] Royal Marsden NHS Fdn Trust, Dept Nucl Med, Surrey, England

[6] Inst Canc Res, Acad Unit Radiotherapy & Oncol, Surrey, England

[7] Sanjay Gandhi Postgrad Inst Med Sci, Dept Radiotherapy, Lucknow, Uttar Pradesh, India

[8] City Hosp Nottingham, Nottingham, England

来源：

RADIOTHERAPY AND ONCOLOGY | 2009年 / 91卷 / 03期

关键词：

Non-small cell lung cancer; Intensity modulated radiotherapy; Radiation pneumonitis; Radiotherapy treatment planning; Functional imaging; CONFORMAL RADIATION; DOSE-ESCALATION; TOXICITY;

D O I：

10.1016/j.radonc.2008.10.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

IMIRT and 3-dimensional conformal radiotherapy (3-DCRT) plans of 25 patients with non-small cell lung (NSCLC) were compared in terms of planning target volume (PTV) coverage and sparing of functional lung (FL) defined by a SPECT perfusion scan. IMRT resulted in significant reduction of functional V-20 and mean lung dose in stage III patients with inhomogeneous hypoperfusion. If the dose to FL is shown to be the determinant of lung toxicity, IMRT would allow for effective dose escalation by specific avoidance of functional lung. (C) 2008 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 91 (2009) 349-352

引用

页码：349 / 352

页数：4

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