No immunosuppressive effect of transfected annexin II

被引：4

作者：

Hansen, T ^{[1
]}

机构：

[1] Univ Bergen, Dept Microbiol & Immunol, Gade Inst, N-5020 Bergen, Norway

来源：

APMIS | 2002年 / 110卷 / 05期

关键词：

annexin II; p11; electroporation;

D O I：

10.1034/j.1600-0463.2002.100506.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Annexin II (AXII) was reported to suppress lymphoproliferation and immunoglobulin production. To investigate this further, the AXII-negative human B-lymphoma cell line Raji was transfected with AXII followed by transfection with p11. Stable transfectants were generated. In vitro immunological effects of Raji, Raji-AXII and Raji-AXII-p11 were compared by using irradiated cells as stimulators for PBM in mixed lymphocyte reactions or by adding the supernatants to lymphoproliferation or ELISPOT cultures. None of the assays provided evidence of significant immunosuppression by AXII. Thus, expression of AXII or AXII plus p11 does not by itself give a cell immunosuppressive ability.

引用

页码：403 / 409

页数：7

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