Linking genome structure and function through specific histone acetylation

被引：11

作者：

Hansen, Jeffrey C. ^{[1
]}

机构：

[1] Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA

来源：

ACS CHEMICAL BIOLOGY | 2006年 / 1卷 / 02期

关键词：

D O I：

10.1021/cb6000894

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A recent publication shows that a simple chemical event, acetylation of lysine 16 on the histone H4 N-terminal tail domain (NTD), completely abolishes the ability of the H4 NTD to mediate the nucleosome-nucleosome interactions involved in chromatin condensation. This result provides novel insight into the molecular mechanism of histone acetylation and also implicates H4 K16acet-dependent changes in chromatin fiber architecture as a central mechanism for generating transcriptionally active genomic domains.

引用

页码：69 / 72

页数：4

共 16 条

[1] Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila [J].

Akhtar, A ;

Becker, PB .

MOLECULAR CELL, 2000, 5 (02) :367-375

[2] The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA [J].

Barbera, AJ ;

Chodaparambil, JV ;

Kelley-Clarke, B ;

Joukov, V ;

Walter, JC ;

Luger, K ;

Kaye, KM .

SCIENCE, 2006, 311 (5762) :856-861

[3] Nucleosome arrays reveal the two-start organization of the chromatin fiber [J].

Dorigo, B ;

Schalch, T ;

Kulangara, A ;

Duda, S ;

Schroeder, RR ;

Richmond, TJ .

SCIENCE, 2004, 306 (5701) :1571-1573

[4] Chromatin fiber folding: Requirement for the histone H4N-terminal tail [J].

Dorigo, B ;

Schalch, T ;

Bystricky, K ;

Richmond, TJ .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 327 (01) :85-96

[5] H2A.Z alters the nucleosome surface to promote HP1α-mediated chromatin fiber folding [J].

Fan, JY ;

Rangasamy, D ;

Luger, K ;

Tremethick, DJ .

MOLECULAR CELL, 2004, 16 (04) :655-661

[6] The core histone n-terminal tail domains function independently and additively during salt-dependent oligomerization of nucleosomal arrays [J].

Faye, G ;

Luger, K ;

Hansen, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (40) :33701-33706

[7] Histone and chromatin cross-talk [J].

Fischle, W ;

Wang, YM ;

Allis, CD .

CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (02) :172-183

[8] Conformational dynamics of the chromatin fiber in solution: Determinants, mechanisms, and functions [J].

Hansen, JC .

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 2002, 31 :361-392

[9] Intrinsic protein disorder, amino acid composition, and histone terminal domains [J].

Hansen, JC ;

Lu, X ;

Ross, ED ;

Woody, RW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (04) :1853-1856

[10] mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila [J].

Hilfiker, A ;

HilfikerKleiner, D ;

Pannuti, A ;

Lucchesi, JC .

EMBO JOURNAL, 1997, 16 (08) :2054-2060

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