Site-specific recombination in plane view

被引:39
作者
Yang, W
Mizuuchi, K
机构
[1] Laboratory of Molecular Biology, Natl. Inst. Diabet. Digest. K., National Institutes of Health, Bethesda, MD 20892
关键词
D O I
10.1016/S0969-2126(97)00290-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Biochemists have worked long and hard on each reaction component and chemical step to reach the point of asking the question as to how protein and DNA molecules are arranged and rearranged in the process of site-specific recombination. The structures of several lambda integrase family members published recently have answered many of the questions about this process.
引用
收藏
页码:1401 / 1406
页数:6
相关论文
共 19 条
[1]   2 RELATED RECOMBINASES ARE REQUIRED FOR SITE-SPECIFIC RECOMBINATION AT DIF AND CER IN ESCHERICHIA-COLI K12 [J].
BLAKELY, G ;
MAY, G ;
MCCULLOCH, R ;
ARCISZEWSKA, LK ;
BURKE, M ;
LOVETT, ST ;
SHERRATT, DJ .
CELL, 1993, 75 (02) :351-361
[2]   SUICIDE SUBSTRATES REVEAL PROPERTIES OF THE HOMOLOGY-DEPENDENT STEPS DURING INTEGRATIVE RECOMBINATION OF BACTERIOPHAGE-LAMBDA [J].
BURGIN, AB ;
NASH, HA .
CURRENT BIOLOGY, 1995, 5 (11) :1312-1321
[3]   RIBBONS 2 0 [J].
CARSON, M .
JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1991, 24 :958-&
[4]   DNA CLEAVAGE IN TRANS BY THE ACTIVE-SITE TYROSINE DURING FLP RECOMBINATION - SWITCHING PROTEIN PARTNERS BEFORE EXCHANGING STRANDS [J].
CHEN, JW ;
LEE, J ;
JAYARAM, M .
CELL, 1992, 69 (04) :647-658
[5]  
CRAIG NL, 1988, ANNU REV GENET, V22, P77
[6]   THE STRUCTURE OF THE HOLLIDAY JUNCTION, AND ITS RESOLUTION [J].
DUCKETT, DR ;
MURCHIE, AIH ;
DIEKMANN, S ;
VONKITZING, E ;
KEMPER, B ;
LILLEY, DMJ .
CELL, 1988, 55 (01) :79-89
[7]   The integrase family of tyrosine recombinases: evolution of a conserved active site domain [J].
Esposito, D ;
Scocca, JJ .
NUCLEIC ACIDS RESEARCH, 1997, 25 (18) :3605-3614
[8]  
GUO K, 1997, NATURE, V389, P40
[9]   Molecular organization in site-specific recombination: The catalytic domain of bacteriophage HP1 integrase at 2.7 angstrom resolution [J].
Hickman, AB ;
Waninger, S ;
Scocca, JJ ;
Dyda, F .
CELL, 1997, 89 (02) :227-237
[10]   SITE-SPECIFIC RECOMBINASES - TOOLS FOR GENOME ENGINEERING [J].
KILBY, NJ ;
SNAITH, MR ;
MURRAY, JAH .
TRENDS IN GENETICS, 1993, 9 (12) :413-421