Polymorphic markers for the arylsulfatase A gene reveal a greatly expanded meiotic map for the human 22q telomeric region

被引：6

作者：

Brennan, MD ^{[1
]}

Neibergs, HL

Phillips, K

Moseley, S

机构：

[1] Univ Louisville, Sch Med, Dept Biochem & Mol Biol, Louisville, KY 40292 USA

[2] Univ Louisville, Sch Med, Dept Pediat, Louisville, KY 40292 USA

来源：

GENOMICS | 2000年 / 63卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1006/geno.1999.6110

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two microsatellite markers, D22S1743 and D22S1744, were developed for the arylsulfatase A (ARSA) region of chromosome 22q. Linkage analysis for 171 families, using nine reference markers covering all of 22q, placed these new markers 2.0 Kosambi cM distal to D22S526, making them more distal than any microsatellite markers currently on the Genethon or Marshfield linkage maps. Recombination between proximal markers D22S270/D22S683 and D22S446/D22S311 exhibited increased rates of female meiotic recombination compared to male recombination (P < 0.01). In contrast, the region encompassing sJCW16, D22S526, D22S1743, and D22S1744 exhibited relatively greater recombination in males (1.1 cM for females and 7.5 cM for males; chi(2); P < 0.005). These four distal markers lie in a region of hyperrecombination having a sex-averaged recombination ratio of between 8.3 (D22S1843/D22S1744) and 12 cM (sJCW16/D22S526) per megabase. (C) 2000 Academic Press.

引用

页码：430 / 432

页数：3

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