Neutrophils synthesize and activate TGFβ2

被引：12

作者：

Szymkowiak, CH

Csernok, E

Reinhold, D

Bank, U

Gross, WL

Kekow, J ^{[4
]}

机构：

[1] Univ Lubeck, Dept Clin Rheumatol, Lubeck, Germany

[2] Rheumaklin Bad Bramstedt, D-23538 Lubeck, Germany

[3] Univ Magdeburg, Inst Expt Internal Med, D-39120 Magdeburg, Germany

[4] Univ Magdeburg, Clin Rheumatol, D-39245 Vogelsang, Germany

来源：

CYTOKINE | 2000年 / 12卷 / 04期

关键词：

growth factors; cytokines; neutrophils; human;

D O I：

10.1006/cyto.1999.0572

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human polymorphonuclear neutrophils (PMN) are regulated by soluble factors such as chemotactic peptides and cytokines, PMN themselves are capable of synthesizing and releasing various cytokines, thereby taking part in the afferent or inductive limb of the immune response, We report for the first time that TGF beta 2 can be synthesized and released by PMN obtained from peripheral blood. Reverse transcriptase polymerase chain reaction (RT-PCR) showed that preparations of PMN express mRNA for transforming growth factor (TGF)beta 1 and TGF beta 2 but not for TGF beta 3, Only translation of TGF beta 2 into protein was observed applying different assays. Interestingly, TGF beta 2 in supernatants from stimulated PMN could be detected in the bioactive form, (C) 2000 Academic Press.

引用

页码：397 / 400

页数：4

共 16 条

[1] Transforming growth factor-beta(1) stimulates degranulation and oxidant release by adherent human neutrophils [J].