Expression and function of bactericidal/permeability-increasing protein in human genital tract epithelial cells

被引：35

作者：

Canny, Geraldine O.

Trifonova, Radiana T.

Kindelberger, David W.

Colgan, Sean P.

Fichorova, Raina N.

机构：

[1] Harvard Univ, Sch Med, Ctr Expt Therapeut & Reperfus Injury, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Obstet Gynecol & Reprod Biol, Lab Genital Tract Biol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Brigham & Womens Hosp, Cytol Div,Dept Pathol, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Brigham & Womens Hosp, Womens & Perinatal Pathol Div,Dept Pathol, Boston, MA 02115 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2006年 / 194卷 / 04期

关键词：

D O I：

10.1086/505712

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genital tract epithelia regularly encounter and adapt to the existence of bacterial pathogens. This study provides evidence that the endocervical and ectocervical epithelia of the human female genital tract express bactericidal/permeability increasing protein (BPI). The constitutive expression of BPI was restricted to cell-bound protein and unaffected by human papillomavirus type 16/E6E7 immortalization and pro-inflammatory cytokine stimulation. Epithelial BPI was, in part, responsible for killing a commensal strain of Escherichia coli. The results of the present study suggest that BPI is tightly regulated and functionally expressed by epithelial cells in the female reproductive tract and may play a role in regulating bacterial colonization in the genital mucosa.

引用

页码：498 / 502

页数：5

共 15 条

[1] Innate immunity at the mucosal surface: Role of toll-like receptor 3 and toll-like receptor 9 in cervical epithelial cell responses to microbial pathogens [J].