Disease drivers of aging

被引：94

作者：

Hodes, Richard J. ^{[1
]}

Sierra, Felipe ^{[1
]}

Austad, Steven N. ^{[2
]}

Epel, Elissa ^{[3
]}

Neigh, Gretchen N. ^{[4
]}

Erlandson, Kristine M. ^{[5
]}

Schafer, Marissa J. ^{[6
,7
]}

LeBrasseur, Nathan K. ^{[6
,7
]}

Wiley, Christopher ^{[8
]}

Campisi, Judith ^{[8
]}

Sehl, Mary E. ^{[9
]}

Scalia, Rosario ^{[10
,11
]}

Eguchi, Satoru ^{[10
,11
]}

Kasinath, Balakuntalam S. ^{[12
]}

Halter, Jeffrey B. ^{[13
]}

Cohen, Harvey Jay ^{[14
]}

Demark-Wahnefried, Wendy ^{[15
]}

Ahles, Tim A. ^{[16
]}

Barzilai, Nir ^{[17
]}

Hurria, Arti ^{[18
]}

Hunt, Peter W. ^{[19
]}

机构：

[1] NIA, Bethesda, MD 20892 USA

[2] Univ Alabama Birmingham, Dept Biol, Birmingham, AL 35294 USA

[3] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

[4] Virginia Commonwealth Univ, Richmond, VA USA

[5] Univ Colorado, Anschutz Med Ctr, Aurora, CO USA

[6] Mayo Clin, Coll Med, Robert & Arlene Kogod Ctr Aging, Rochester, MN USA

[7] Mayo Clin, Coll Med, Dept Phys Med & Rehabil, Rochester, MN USA

[8] Buck Inst Res Aging, Novato, CA USA

[9] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

[10] Temple Univ, Lewis Katz Sch Med, Dept Physiol, Philadelphia, PA 19122 USA

[11] Temple Univ, Lewis Katz Sch Med, Cardiovasc Res Ctr, Philadelphia, PA 19122 USA

[12] Univ Texas Hlth Sci Ctr San Antonio, South Texas Vet Hlth Care Syst, Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA

[13] Univ Michigan, Div Geriatr & Palliat Med, Ann Arbor, MI 48109 USA

[14] Duke Univ, Sch Med, Durham, NC USA

[15] Univ Alabama Birmingham, Ctr Comprehens Canc, Birmingham, AL 35294 USA

[16] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA

[17] Albert Einstein Coll Med, Inst Aging Res, New York, NY USA

[18] City Hope Natl Med Ctr, Natl Med Ctr, Duarte, CA USA

[19] Univ Calif San Francisco, Sch Med, San Francisco, CA USA

来源：

ANNALS REPORTS, VOL 1386 | 2016年 / 1386卷

关键词：

disease; aging; pathology; chronic; prevention; age-related; HIV; diabetes; cancer; QUALITY-OF-LIFE; BETA-CELL PROLIFERATION; NITRIC-OXIDE; INSULIN-RESISTANCE; CANCER SURVIVORS; OXIDATIVE-STRESS; OLDER PATIENTS; MITOCHONDRIAL DYSFUNCTION; ENDOTHELIAL DYSFUNCTION; ISCHEMIA-REPERFUSION;

D O I：

10.1111/nyas.13299

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

It has long been known that aging, at both the cellular and organismal levels, contributes to the development and progression of the pathology of many chronic diseases. However, much less research has examined the inverse relationship-the contribution of chronic diseases and their treatments to the progression of aging-related phenotypes. Here, we discuss the impact of three chronic diseases (cancer, HIV/AIDS, and diabetes) and their treatments on aging, putative mechanisms by which these effects are mediated, and the open questions and future research directions required to understand the relationships between these diseases and aging.

引用

页码：45 / 68

页数：24

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