Breaking the (Un)sound barrier: Filaggrin is a major gene for atopic dermatitis

被引：174

作者：

Irvine, Alan D.

Irwin McLean, W. H. ^{[1
]}

机构：

[1] Univ Dundee, Ninewells Hosp & Med Sch, Human Genet Unit, Div Pathol & Neurosci,Epithelial Genet Grp, Dundee DD1 9SY, Scotland

[2] Our Ladys Hosp Sick Children, Dept Pediat Dermatol, Dublin 12, Ireland

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2006年 / 126卷 / 06期

关键词：

D O I：

10.1038/sj.jid.5700365

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We have recently shown that loss-of-function mutations in the filaggrin gene, carried by about 10% of people of European ethnicity, cause ichthyosis vulgaris and are strong predisposing factors for atopic dermatitis and asthma secondary to atopic dermatitis. These results demonstrate a prominent role for the epidermal barrier in atopic disease and have important implications for the study of complex traits.

引用

页码：1200 / 1202

页数：3

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