Use of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatment

被引：50

作者：

Davies, Geraint R.

Brindle, Richard

Khoo, Saye H.

Aarons, Leon J.

机构：

[1] Univ Liverpool, Wellcome Trust Ctr Clin Trop Med, Liverpool L69 3BX, Merseyside, England

[2] Portsmouth Hosp, Dept Clin Microbiol, Portsmouth, Hants, England

[3] Univ Liverpool, Dept Pharmacol & Therapeut, Liverpool L69 3BX, Merseyside, England

[4] Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester, Lancs, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 09期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/AAC.00774-05

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nonlinear mixed-effects analysis of serial sputum colony-counting data supports the existence of two bacillary subpopulations in sputum, eliminated at different rates. It distinguishes between combination regimens, removes bias, and greatly improves precision, with significant implications for the analysis of surrogate endpoints of "sterilization" in the development of new antituberculosis regimens.

引用

页码：3154 / 3156

页数：3

共 21 条

[1] Serial counts of Mycobacterium tuberculosis in sputum as surrogate markers of the sterilising activity of rifampicin and pyrazinamide in treating pulmonary tuberculosis [J].