Jumping translocation in acute leukemia of myelomonocytic lineage:: a case report and review of the literature

被引：26

作者：

Bernard, M

Lemée, F

Picard, F

Ghandour, C

Drenou, B

Le Prise, PY

Lamy, T ^{[1
]}

机构：

[1] CHU Rennes, Hop Pontchaillou, Serv Hematol Clin, F-35033 Rennes, France

[2] CHU Rennes, Lab Genet & Biol Cellulaire, Rennes, France

[3] Clin Cesson Sevigne, Unite Hematol, Rennes, France

[4] CHU Rennes, Hematol Lab, Rennes, France

来源：

LEUKEMIA | 2000年 / 14卷 / 01期

关键词：

jumping translocation; chromosome; 3q13.3; acute monocytic leukemia;

D O I：

10.1038/sj.leu.2401637

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Jumping translocation (JT) is a very rare cytogenetic event, occurring especially in cancer. We describe a case of secondary acute monocytic leukemia (AML5b) with a JT involving the 3q13-3qter segment and leading to a partial trisomy 3. Each clone with JT was associated with trisomy 8 or tetrasomy 8. The literature of JT in AML cases is reviewed: only 13 cases of AML associated with JT have been previously described, seven of which are AML4/5 FAB subtype. Jumping translocation involvement in leukemogenesis is discussed.

引用

页码：119 / 122

页数：4

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