A search for possible cytogenetic effects of low frequency vibrations in cultured human lymphocytes

被引:6
作者
Khalil, AM
Qassem, W
机构
[1] YARMOUK UNIV,DEPT BIOL SCI,IRBID,JORDAN
[2] YARMOUK UNIV,HIJJAWI FAC APPL ENGN,IRBID,JORDAN
来源
HUMAN & EXPERIMENTAL TOXICOLOGY | 1996年 / 15卷 / 06期
关键词
sister-chromatid exchanges; vibrations; human lymphocytes;
D O I
10.1177/096032719601500608
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 [卫生毒理学];
摘要
1 Acute cytogenetic effects expressed as sister-chromatid exchanges (SCE) in peripheral blood lymphocytes were investigated after in vitro exposure to low vibration regimes (5-30 Hz, at 0.1 cm amplitude) for Z0 min intervals and compared to non-vibrated control cultures. 2 There was no significant (P<0.05) increase in the range of SCE incidence at any vibration frequency compared to the mean value of control; 6.88 +/- 0.11 to 7.97 +/- 0.22 versus 6.83 +/- 0.86, respectively. 3 When cultures were incubated for 1 h in the presence of 0.5 mu g ml(-1) mitomycin C (MMC; the positive control) significant elevations in the SCE frequency were observed (19.81 +/- 0.67), indicating the sensitivity of the system to in vitro SCE induction. 4 Other cell parameters, such as mitotic index and cell proliferation index were statistically similar in the experimental cultures and the negative control. 5 The observed differences in the investigated endpoints are considered within those typically found in vitro. This suggests no relation between low frequency vibrations and cytogenetic effects.
引用
收藏
页码:504 / 507
页数:4
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