Modeling transmembrane helical oligomers

被引：48

作者：

Dieckmann, GR

DeGrado, WF

机构：

[1] Dept. of Biochemistry and Biophysics, Johnson Res. Found., Univ. P., Philadelphia

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 04期

关键词：

D O I：

10.1016/S0959-440X(97)80111-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, methods for the analysis and design of water-soluble, oligomeric bundles of a helices, including coiled coils, have reached a high level of sophistication. These same methods may now be applied to transmembrane helical bundles. Studies of the transmembrane domains of glycophorin, phospholamban, and the M-2 protein from influenza A virus exemplify this general approach.

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收藏

页码：486 / 494

页数：9

相关论文

共 82 条

[1] GLYCOPHORIN-A HELICAL TRANSMEMBRANE DOMAINS DIMERIZE IN PHOSPHOLIPID-BILAYERS - A RESONANCE ENERGY-TRANSFER STUDY [J].

ADAIR, BD ;

ENGELMAN, DM .

BIOCHEMISTRY, 1994, 33 (18) :5539-5544

[2]

Adams PD, 1996, PROTEINS, V26, P257, DOI 10.1002/(SICI)1097-0134(199611)26:3<257::AID-PROT2>3.3.CO

[3]

2-O

[4] COMPUTATIONAL SEARCHING AND MUTAGENESIS SUGGEST A STRUCTURE FOR THE PENTAMERIC TRANSMEMBRANE DOMAIN OF PHOSPHOLAMBAN [J].

ADAMS, PD ;

ARKIN, IT ;

ENGELMAN, DM ;

BRUNGER, AT .

NATURE STRUCTURAL BIOLOGY, 1995, 2 (02) :154-162

[5]

ADAMS PD, 1997, MOL B INT U, P251

[6] Mapping the lipid-exposed surfaces of membrane proteins [J].

Arkin, IT ;

MacKenzie, KR ;

Fisher, L ;

Aimoto, S ;

Engelman, DM ;

Smith, SO .

NATURE STRUCTURAL BIOLOGY, 1996, 3 (03) :240-243

[7] STRUCTURAL MODEL OF THE PHOSPHOLAMBAN ION-CHANNEL COMPLEX IN PHOSPHOLIPID-MEMBRANES [J].

ARKIN, IT ;

ROTHMAN, M ;

LUDLAM, CFC ;

AIMOTO, S ;

ENGELMAN, DM ;

ROTHSCHILD, KJ ;

SMITH, SO .

JOURNAL OF MOLECULAR BIOLOGY, 1995, 248 (04) :824-834

[8] STRUCTURAL ORGANIZATION OF THE PENTAMERIC TRANSMEMBRANE ALPHA-HELICES OF PHOSPHOLAMBAN, A CARDIAC ION-CHANNEL [J].

ARKIN, IT ;

ADAMS, PD ;

MACKENZIE, KR ;

LEMMON, MA ;

BRUNGER, AT ;

ENGELMAN, DM .

EMBO JOURNAL, 1994, 13 (20) :4757-4764

[9] MULTIPLE INDEPENDENT ACTIVATIONS OF THE NEU ONCOGENE BY A POINT MUTATION ALTERING THE TRANSMEMBRANE DOMAIN OF P185 [J].

BARGMANN, CI ;

HUNG, MC ;

WEINBERG, RA .

CELL, 1986, 45 (05) :649-657

[10]

BARGMANN CI, 1988, P NATL ACAD SCI USA, V85, P2371

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