Oncogenic role of Epstein-Barr virus-encoded RNAs in Burkitt's lymphoma cell line Akata

被引：199

作者：

Komano, J ^{[1
]}

Maruo, S ^{[1
]}

Kurozumi, K ^{[1
]}

Oda, T ^{[1
]}

Takada, K ^{[1
]}

机构：

[1] Hokkaido Univ, Sch Med, Inst Canc, Dept Virol,Kita Ku, Sapporo, Hokkaido 0608638, Japan

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 12期

关键词：

D O I：

10.1128/JVI.73.12.9827-9831.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Our previous reports indicated that Epstein-Barr virus (EBV) contributes to the malignant phenotype and resistance to apoptosis in Burkitt's lymphoma (BL) cell line Akata (N, Shimizu, A. Tanabe-Tochikura, Y. Kuroiwa, and K, Takada, J, Virol, 68:6069-6073, 1994; J, Komano, M, Sugiura, and K, Takada, J, Virol, 72:9150-9156, 1998), Here we report that the EBV-encoded small RNAs (EBERs) are responsible for these phenotypes, Transfection of the EBER genes into EBV-negative Akata clones restored the capacity for growth in soft agar, tumorigenicity in SCID mice, resistance to apoptotic inducers, and upregulated expression of bcl-2 oncoprotein that were originally retained in parental EBV-positive Akata cells and lost in EBV-negative subclones, This is the first report which provides evidence that virus-encoded RNAs (EBERs) have oncogenic functions in BL cells.

引用

页码：9827 / 9831

页数：5

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