The effect of 6 months oral alendronate treatment on periprosthetic bone loss after total knee arthroplasty

被引:7
作者
Abu-Rajab, Rashid Barakat [1 ]
Watson, W. S. [3 ]
Gallacher, P. [2 ]
Walker, B. [3 ]
Meek, R. M. D. [2 ]
机构
[1] Royal Alexandra Hosp, Dept Orthopaed, Paisley PA2 9PN, Renfrew, Scotland
[2] So Gen Hosp, Dept Orthopaed, Glasgow G51 4TF, Lanark, Scotland
[3] So Gen Hosp, Dept Nucl Med, Glasgow G51 4TF, Lanark, Scotland
关键词
Knee; Arthroplasty; Replacement; Bone mineral density; Alendronate; Bisphosphonates; X-RAY ABSORPTIOMETRY; MINERAL DENSITY; FOLLOW-UP; FEMUR; OSTEOPOROSIS; BISPHOSPHONATES; TERIPARATIDE; PREVENTION; FIXATION; DESIGN;
D O I
10.1007/s00590-008-0412-8
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
100224 [整形外科学];
摘要
This study was designed to test whether established post-total knee arthroplasty (TKA) bone loss at over 2 years post-surgery could be improved by 6 months of alendronate administration. This was a double blind randomized controlled trial. From a previous study assessing periprosthetic bone mineral density (BMD) at 2 years post-surgery, 11 patients were randomised to receive either 70 mg of alendronate per week or a placebo, for 6 months. DXA scans were performed on both knees (operated knee and contralateral knee) at 6 months and compared with pre-treatment DXA scans. No significant change in BMD following a 6-month administration of alendronate, given 2 years post-TKA was seen. Additionally, alendronate had no effect on Oxford Knee Scores. The administration of a 6-month course of alendronate has no significant effect on established periprosthetic BMD loss.
引用
收藏
页码:231 / 235
页数:5
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