Linkers made to measure

被引：16

作者：

Schwabe, JWR ^{[1
]}

Rhodes, D ^{[1
]}

机构：

[1] MRC,MOL BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

来源：

NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 09期

关键词：

D O I：

10.1038/nsb0997-680

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Members of the family of fungal Zn(2)Cys(6) DNA-binding proteins discriminate between their DNA targets using neither their DNA-binding module, nor their dimerization domain, but primarily through the relatively flexible linker between them.

引用

页码：680 / 683

页数：4

共 16 条

[1] SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF CD2-GAL4 FROM SACCHAROMYCES-CEREVISIAE [J].

BALEJA, JD ;

MARMORSTEIN, R ;

HARRISON, SC ;

WAGNER, G .

NATURE, 1992, 356 (6368) :450-453

[2] SOLUTION STRUCTURE OF THE KLUYVEROMYCES-LACTIS LAC9 CD(2)CYS(6) DNA-BINDING DOMAIN [J].

GARDNER, KH ;

ANDERSON, SF ;

COLEMAN, JE .

NATURE STRUCTURAL BIOLOGY, 1995, 2 (10) :898-905

[3]

Hellauer K, 1996, MOL CELL BIOL, V16, P6096

[4] STRUCTURE OF THE DNA-BINDING DOMAIN OF ZINC GAL4 [J].

KRAULIS, PJ ;

RAINE, ARC ;

GADHAVI, PL ;

LAUE, ED .

NATURE, 1992, 356 (6368) :448-450

[5]

Liang SD, 1996, MOL CELL BIOL, V16, P3773

[6] DNA RECOGNITION BY GAL4 - STRUCTURE OF A PROTEIN DNA COMPLEX [J].

MARMORSTEIN, R ;

CAREY, M ;

PTASHNE, M ;

HARRISON, SC .

NATURE, 1992, 356 (6368) :408-414

[7] CRYSTAL-STRUCTURE OF A PPR1-DNA COMPLEX - DNA RECOGNITION BY PROTEINS CONTAINING A ZN(2)CYS(6) BINUCLEAR CLUSTER [J].

MARMORSTEIN, R ;

HARRISON, SC .

GENES & DEVELOPMENT, 1994, 8 (20) :2504-2512

[8] DETERMINANTS OF BINDING-SITE SPECIFICITY AMONG YEAST C6 ZINC CLUSTER PROTEINS [J].

REECE, RJ ;

PTASHNE, M .

SCIENCE, 1993, 261 (5123) :909-911

[9] Towards an understanding of protein-DNA recognition [J].

Rhodes, D ;

Schwabe, JWR ;

Chapman, L ;

Fairall, L .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1996, 351 (1339) :501-509

[10] Comparative amino acid sequence analysis of the C-6 zinc cluster family of transcriptional regulators [J].

Schjerling, P ;

Holmberg, S .

NUCLEIC ACIDS RESEARCH, 1996, 24 (23) :4599-4607

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