The TREM receptor family and signal integration

被引：470

作者：

Klesney-Tait, Julia ^{[1
]}

Turnbull, Isaiah R. ^{[1
]}

Colonna, Marco ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

来源：

NATURE IMMUNOLOGY | 2006年 / 7卷 / 12期

关键词：

D O I：

10.1038/ni1411

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

TREM proteins are a family of cell surface receptors that participate in diverse cell processes, including inflammation, bone homeostasis, neurological development and coagulation. TREM-1, the first to be identified, acts to amplify inflammation. Other TREM proteins regulate the differentiation and function of macrophages, microglia, dendritic cells, osteoclasts and platelets. Here we discuss the state of the field, putative ligands of TREM proteins and the challenges that remain in understanding TREM biology.

引用

页码：1266 / 1273

页数：8

共 83 条

[1] Agarwal PK, 2003, NEW ENGL J MED, V348, P1600
[2] Molecular characterization of a novel immune receptor restricted to the monocytic lineage
Aguilar, H
Alvarez-Errico, D
García-Montero, AC
Orfao, A
Sayós, J
López-Botet, M
[J]. JOURNAL OF IMMUNOLOGY, 2004, 173 (11) : 6703 - 6711
[3] The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44
Allcock, RJN
Barrow, AD
Forbes, S
Beck, S
Trowsdale, J
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (02) : 567 - 577
[4] Differential regulation of DAP12 and molecules associated with DAP12 during host responses to mycobacterial infection
Aoki, N
Zganiacz, A
Margetts, P
Xing, Z
[J]. INFECTION AND IMMUNITY, 2004, 72 (05) : 2477 - 2483
[5] Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2
Barrow, AD
Astoul, E
Floto, A
Brooke, G
Relou, IAM
Jennings, NS
Smith, KGC
Ouwehand, W
Farndale, RW
Alexander, DR
Trowsdale, A
[J]. JOURNAL OF IMMUNOLOGY, 2004, 172 (10) : 5838 - 5842
[6] You say ITAM and I say ITIM, let's call the whole thing off: the ambiguity of immunoreceptor signalling
Barrow, Alexander David
Trowsdale, John
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2006, 36 (07) : 1646 - 1653
[7] Mycobacterium bovis BCG cell wall-specific differentially expressed genes identified by differential display and cDNA subtraction in human macrophages
Begum, NA
Ishii, K
Kurita-Taniguchi, M
Tanabe, M
Kobayashi, M
Moriwaki, Y
Matsumoto, M
Fukumori, Y
Azuma, I
Toyoshima, K
Seya, T
[J]. INFECTION AND IMMUNITY, 2004, 72 (02) : 937 - 948
[8] Sampling and signaling in plasmacytoid dendritic cells: the potential roles of Siglec-H
Blasius, Amanda L.
Colonna, Marco
[J]. TRENDS IN IMMUNOLOGY, 2006, 27 (06) : 255 - 260
[9] A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response
Bleharski, JR
Kiessler, V
Buonsanti, C
Sieling, PA
Stenger, S
Colonna, M
Modlin, RL
[J]. JOURNAL OF IMMUNOLOGY, 2003, 170 (07) : 3812 - 3818
[10] A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells
Bouchon, A
Hernández-Munain, C
Cella, M
Colonna, M
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (08) : 1111 - 1122

← 1 2 3 4 5 6 7 8 9 →