NAG7 Promotes Human Nasopharyngeal Carcinoma Invasion Through Inhibition of Estrogen Receptor Alpha and Up-Regulation of JNK2/AP-1/MMP1 Pathways

被引：38

作者：

Huang, Chen ^{[1
]}

Wu, Minghua ^{[1
]}

Tang, Yunlian ^{[1
]}

Li, Xiaoling ^{[1
]}

Ouyang, Jue ^{[1
]}

Xiao, Lan ^{[1
]}

Li, Dan ^{[1
]}

Li, Guiyuan ^{[1
]}

机构：

[1] Cent S Univ, Canc Res Inst, Changsha 410078, Hunan, Peoples R China

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2009年 / 221卷 / 02期

关键词：

HUMAN-BREAST-CANCER; ACTIVATED PROTEIN-KINASE; MATRIX METALLOPROTEINASE-1; CELL-LINE; POOR-PROGNOSIS; GROWTH-FACTORS; EXPRESSION; PROLIFERATION; METASTASIS; MAPK;

D O I：

10.1002/jcp.21867

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The NAG7, an estrogen receptor repressor, is a negative regulator of nasopharyngeal carcinoma cell growth. Here, we report that NAG7 promotes human nasopharyngeal carcinoma invasion, and we identify the mechanisms underlying this function. As a consequence of elevated NAG7 expression, the adhesion, migration, and invasive capabilities of HNEI cells in vitro and in vivo were enhanced. NAG7 was a significant negative regulator of protein expression of estrogen receptor alpha (ER alpha), and activated both the JNK2/AP-1/MMP1 and the upstream H-Ras/p-c-Raf pathways. None of these effects induced by NAG7 over-expression could be counteracted by estrogen. These observations indicate that NAG7 plays a potential role in promoting nasopharyngeal carcinoma invasion by regulation of ER(X and the H-ras/p-c-Raf and JNK2/AP-1/MMP1 signaling pathways. J. Cell. Physiol. 22 1: 394-401, 2009. (C) 2009 Wiley-Liss, Inc.

引用

页码：394 / 401

页数：8

共 33 条

[1]

Green fluorescent protein tagging of extracellular signal-regulated kinase and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth [J].