The genetics of hereditary nonmedullary thyroid carcinoma

被引:30
作者
Malchoff, CD [1 ]
Malchoff, DM [1 ]
机构
[1] Univ Connecticut, Ctr Hlth, Dept Med, Farmington, CT 06030 USA
关键词
D O I
10.1210/jc.87.6.2455
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Unequivocal evidence of fPTC as a distinct syndrome awaits the identification of the susceptibility genes, as suggested by Fagin (2). However, the clinical and genetic evidence is sufficiently compelling that clinical insights can be derived from these studies. A familial susceptibility occurs in about 5% of PTC. There are at least three familial PTC syndromes characterized by a predominance of PTC, and inheritance is autosomal dominant with partial penetrance. Clinical recommendations are suggested for the identification of fPTC kindreds and for screening the first-degree relatives of affected kindred members.
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页码:2455 / 2459
页数:5
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