Significance of human striatal D-neurons: implications in neuropsychiatric functions

被引：10

作者：

Ikemoto, K ^{[1
]}

机构：

[1] Natl Minami Hanamaki Hosp, Clin Res Inst, Hanamaki, Iwate 0250033, Japan

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2004年 / 28卷 / 03期

关键词：

aromatic L-amino acid decarboxylase; D-neuron; L-dopa; nucleus accumbens; striatum;

D O I：

10.1016/j.pnpbp.2003.11.017

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The human striatum, especially its ventral part, the nucleus accumbens (Ace), contains numerous nonmonoaminergic aromatic L-amino acid decarboxylase (AADC) [ = dopa decarboxylase (DDC)] neurons (D-neurons). AADC is the second-step synthesizing enzyme for monoamines and is also the rate-limiting enzyme of phenylethylamine (PEA) synthesis. D-neurons may participate in the manifestation of efficacy of pharmacotherapy for Parkinson's disease by taking up monoamine precursors including L-dopa or droxidopa (L-threo-DOPS) and by converting them to dopamine or noradrenaline, respectively. Although previous studies have shown that AADC activity was elevated in the striatum of drug-naive schizophrenia, the number of striatal D-neurons was reduced in autopsy brains of schizophrenia. It is unclear whether or not such reduction of striatal D-neurons implies downregulation. Possible pluripotentiality of D-neurons, including compensatory functions against aging and degeneration, was discussed based on recent published works. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：429 / 434

页数：6

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