Low molecular weight heparin; a novel alternative therapeutic approach for lichen planus

被引：34

作者：

Stefanidou, MP ^{[1
]}

Ioannidou, DJ

Panayiotides, JG

Tosca, AD

机构：

[1] Herakl Univ Gen Hosp, Dept Dermatol, Heraklion 71110, Crete, Greece

[2] Herakl Univ Gen Hosp, Dept Pathol, Heraklion 71110, Crete, Greece

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1999年 / 141卷 / 06期

关键词：

enoxaparin; heparin; lichen planus;

D O I：

10.1046/j.1365-2133.1999.03202.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 [皮肤病与性病学];

摘要：

Heparin analogues in low doses have antiproliferative and immunomodulatory properties. The aim of this study was to evaluate the effect of low-dose enoxaparin administered subcutaneously in lichen planus (LP). Eighteen patients with various types of LP were treated in an open study for 6-13 weeks. Efficacy and safety data were recorded, Complete remission was observed in 11 of 18 patients (61%) and marked improvement in two (11%). Widespread cutaneous involvement and reticulated oral LP had the best response, while in LP of the scalp the response was poor. Enoxaparin is a promising alternative therapy for various types of LF.

引用

页码：1040 / 1045

页数：6

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