Dopamine and inhibitory action control: evidence from spontaneous eye blink rates

被引：107

作者：

Colzato, Lorenza Serena ^{[1
]}

van den Wildenberg, Wery P. M. ^{[2
]}

van Wouwe, Nelleke C. ^{[1
]}

Pannebakker, Merel M. ^{[1
]}

Hommel, Bernhard ^{[1
]}

机构：

[1] Leiden Univ, Dept Psychol, Cognit Psychol Unit, Leiden Inst Brain & Cognit, NL-2300 RB Leiden, Netherlands

[2] Univ Amsterdam, Dept Psychol, Amsterdam Ctr Study Adapt Control Brain & Behav A, Amsterdam, Netherlands

来源：

EXPERIMENTAL BRAIN RESEARCH | 2009年 / 196卷 / 03期

关键词：

Response inhibition; Dopamine; Spontaneous eyeblink; SPONTANEOUS EYEBLINK RATE; OBSESSIVE-COMPULSIVE DISORDER; SIGNAL REACTION-TIME; RESPONSE-INHIBITION; STOP-SIGNAL; PARKINSONS-DISEASE; PREFRONTAL CORTEX; NEUROCHEMICAL MODULATION; STEREOTYPED BEHAVIOR; ONGOING RESPONSES;

D O I：

10.1007/s00221-009-1862-x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The inhibitory control of actions has been claimed to rely on dopaminergic pathways. Given that this hypothesis is mainly based on patient and drug studies, some authors have questioned its validity and suggested that beneficial effects of dopaminergic stimulants on response inhibition may be limited to cases of suboptimal inhibitory functioning. We present evidence that, in carefully selected healthy adults, spontaneous eyeblink rate, a marker of central dopaminergic functioning, reliably predicts the efficiency in inhibiting unwanted action tendencies in a stop-signal task. These findings support the assumption of a modulatory role for dopamine in inhibitory action control.

引用

页码：467 / 474

页数：8

共 75 条

[1] Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans [J].