Enhancement of extinction memory consolidation: The role of the noradrenergic and GABAergic systems within the basolateral amygdala

被引:162
作者
Berlau, Daniel J. [1 ]
McGaugh, James L. [1 ]
机构
[1] Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Dept Neurobiol & Behav, Irvine, CA 92697 USA
关键词
bicuculline; norepinephrine; propranolol; muscimol; hippocampus; contextual fear conditioning;
D O I
10.1016/j.nlm.2005.12.008
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Evidence from previous studies indicates that the noradrenergic and GABAergic influences within the basolateral amygdala (BLA) modulate the consolidation of memory for fear conditioning. The present experiments investigated whether the same modulatory influences are involved in regulating the extinction of fear-based learning. To investigate this issue, male Sprague Dawley rats implanted with unilateral or bilateral carmula aimed at the BLA were trained on a contextual fear conditioning (CFC) task and 24 and 48 h later were given extinction training. Immediately following each extinction session they received intra-BLA infusions of the GABAergic antagonist bicuculline (50 ng), the beta-adrenocepter antagonist propranolol (500 ng), bicuculline with propranolol, norepinephrine (NE) (0.3, 1.0, and 3.0 mu g), the GABAergic agonist muscimol (125 ng), NE with muscimol or a control solution. To investigate the involvement of the dorsal hippocampus (DH) as a possible target of BLA activation during extinction, other animals were given infusions of muscimol (500 ng) via an ipsilateral carmula implanted in the DH. Bilateral BLA infusions of bicuculline significantly enhanced extinction, as did infusions into the right, but not left BLA. Propranolol infused into the right BLA together with bicuculline blocked the bicuculline-induced memory enhancement. Norepinephrine infused into the right BLA also enhanced extinction, and this effect was not blocked by co-infusions of muscimol. Additionally, muscimol infused into the DH did not attenuate the memory enhancing effects of norepinephrine infused into the BLA. These findings provide evidence that, as with original CFC learning, noradrenergic activation within the BLA modulates the consolidation of CFC extinction. The findings also suggest that the BLA influence on extinction is not mediated by an interaction with the dorsal hippocampus, (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:123 / 132
页数:10
相关论文
共 76 条
[1]  
ALHEID GF, 1995, RAT NERVOUS SYSTEM, P223
[2]   The amygdalar circuit that acquires taste aversion memory differs from the circuit that extinguishes it [J].
Bahar, A ;
Samuel, A ;
Hazvi, S ;
Dudai, Y .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 17 (07) :1527-1530
[3]   Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration [J].
Barrientos, RM ;
O'Reilly, RC ;
Rudy, JW .
BEHAVIOURAL BRAIN RESEARCH, 2002, 134 (1-2) :299-306
[4]   Dorsal hippocampus and classical fear conditioning to tone and context in rats: Effects of local NMDA-receptor blockade and stimulation [J].
Bast, T ;
Zhang, WN ;
Feldon, J .
HIPPOCAMPUS, 2003, 13 (06) :657-675
[5]   Basolateral amygdala lesions do not prevent memory of context-footshock training [J].
Berlau, DJ ;
McGaugh, JL .
LEARNING & MEMORY, 2003, 10 (06) :495-502
[6]   INNATE AND CONDITIONED REACTIONS TO THREAT IN RATS WITH AMYGDALOID LESIONS [J].
BLANCHARD, DC ;
BLANCHARD, RJ .
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1972, 81 (02) :281-+
[7]   FACILITATION OF MAZE LEARNING WITH POSTTRIAL INJECTIONS OF PICROTOXIN [J].
BREEN, RA ;
MCGAUGH, JL .
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1961, 54 (05) :498-&
[8]   POST-TRAINING ADMINISTRATION OF GABAERGIC ANTAGONISTS ENHANCES RETENTION OF AVERSIVELY MOTIVATED TASKS [J].
BRIONI, JD ;
MCGAUGH, JL .
PSYCHOPHARMACOLOGY, 1988, 96 (04) :505-510
[9]   INVOLVEMENT OF THE AMYGDALA GABAERGIC SYSTEM IN THE MODULATION OF MEMORY STORAGE [J].
BRIONI, JD ;
NAGAHARA, AH ;
MCGAUGH, JL .
BRAIN RESEARCH, 1989, 487 (01) :105-112
[10]   Sex-related hemispheric lateralization of amygdala function in emotionally influenced memory: An fMRI investigation [J].
Cahill, L ;
Uncapher, M ;
Kilpatrick, L ;
Alkire, MT ;
Turner, J .
LEARNING & MEMORY, 2004, 11 (03) :261-266