Germline BRCA2 mutations in men with breast cancer

被引：39

作者：

Mavraki, E

Gray, IC

Bishop, DT

Spurr, NK

机构：

[1] IMPERIAL CANC RES FUND,APPL DEV LAB,LONDON EC1A 7BE,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,BIOPHARMACEUT RES & DEV,HARLOW CM19 5AW,ESSEX,ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1997年 / 76卷 / 11期

关键词：

BRCA2; male breast cancer; mutation;

D O I：

10.1038/bjc.1997.574

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer in men is rare and is clearly due in some cases to an inherited predisposition. A total of 28 male breast cancer patients were tested for BRCA2 mutations; two frameshifts and one putative missense mutation were identified. One of the frameshifts was detected in the same position as a mutation estimated to be responsible for 40% of all male breast cancer cases in Iceland.

引用

页码：1428 / 1431

页数：4

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