Transport of protein toxins into cells: pathways used by ricin, cholera toxin and Shiga toxin

被引：203

作者：

Sandvig, K ^{[1
]}

van Deurs, B

机构：

[1] Norwegian Radium Hosp, Inst Canc Res, N-0310 Oslo, Norway

[2] Univ Copenhagen, Panum Inst, Dept Med Anat, Struct Cell Biol Unit, DK-2200 Copenhagen, Denmark

来源：

FEBS LETTERS | 2002年 / 529卷 / 01期

关键词：

ricin; cholera toxin; Shiga toxin; endocytosis; Golgi apparatus; clathrin;

D O I：

10.1016/S0014-5793(02)03182-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ricin, cholera, and Shiga toxin belong to a family of protein toxins that enter the cytosol to exert their action. Since all three toxins are routed from the cell surface through the Golgi apparatus and to the endoplasmic reticulum (ER) before translocation to the cytosol, the toxins are used to study different endocytic pathways as well as the retrograde transport to the Golgi and the ER. The toxins can also be used as vectors to carry other proteins into the cells. Studies with protein toxins reveal that there are more pathways along the plasma membrane to ER route than originally believed. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：49 / 53

页数：5

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