Nip and tuck at the neuromuscular junction: A role for proteases in developmental synapse elimination

被引：15

作者：

Chang, Q ^{[1
]}

BaliceGordon, RJ ^{[1
]}

机构：

[1] UNIV PENN,SCH MED,DEPT NEUROSCI,PHILADELPHIA,PA 19104

来源：

BIOESSAYS | 1997年 / 19卷 / 04期

关键词：

D O I：

10.1002/bies.950190402

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During late embryonic and early postnatal development, synaptic connections are extensively modified so that some functional connections are weakened and eliminated from a neural circuit while others are strengthened and maintained. The mechanisms that underlie synapse elimination are beginning to be understood from studies of the neuromuscular junction. A recent paper((1)) provides some intriguing insights into the role proteases may play in the developmental disassembly of neuromuscular synapses.

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页码：271 / 275

页数：5

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