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Drug metabolism and ageing

被引：152
作者：
Kinirons, MT
O'Mahony, MS
机构：
[1] Kings Coll London, Dept Hlth Care Elderly, Guys Kings & St Thomas Sch Med, London SE5 9RS, England
[2] Cardiff Univ, Dept Geriatr Med, Cardiff CF4 4XN, S Glam, Wales
来源：
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2004年 / 57卷 / 05期
关键词：
D O I：
10.1111/j.1365-2125.2004.02096.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Important changes in drug metabolism occur with ageing. Age-associated reductions in function of some but not all cytochrome P450 enzymes (CYPs) have been described. induction and inhibition of CYPs needs to be revisited in light of recent advances. The function and pharmacology of transporters have not yet been examined for an age-related effect. Finally, the concept of frailty is being underpinned by studies documenting a decline in drug metabolism and changes in disposition in frail older people compared with either healthy elderly or the young.
引用
收藏
页码：540 / 544
页数：5
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