DAP-kinase as a target for drug design in cancer and diseases associated with accelerated cell death

被引：144

作者：

Bialik, S ^{[1
]}

Kimchi, A ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

来源：

SEMINARS IN CANCER BIOLOGY | 2004年 / 14卷 / 04期

关键词：

DAP-kinase; cell death; tumor suppressor; drug therapy; B cell lymphomas;

D O I：

10.1016/j.semcancer.2004.04.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Misregulated cell death, which can result in either the excessive, inappropriate elimination of cells, or in the insufficient removal of damaged or malignant cells, has been associated with numerous diseases. Here we discuss an important molecular regulator of cell death, DAP-kinase (DAM), which presents a promising target for therapeutic intervention. A structure-functional analysis of this calcium-regulated Ser/Thr kinase which promotes cell death will be presented, and emphasis will be placed on particular disease models in which its modulation might affect clinically-relevant cell death processes. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：283 / 294

页数：12

共 86 条

[1]

DAP-kinase CpG island methylation in acute myeloid leukemia: methodology versus biology? [J].