Cyclodextrin-peptide hybrid as a hydrolytic catalyst having multiple functional groups

被引：15

作者：

Tsutsumi, H ^{[1
]}

Hamasaki, K ^{[1
]}

Mihara, H ^{[1
]}

Ueno, A ^{[1
]}

机构：

[1] Tokyo Inst Technol, Fac Biosci & Biotechnol, Dept Bioengn, Midori Ku, Yokohama, Kanagawa 2268501, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)00090-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A designed cyclodextrin-peptide hybrid, which has multiple functional groups on its alpha-helix peptide backbone, has been synthesized as a catalyst for eater hydrolysis. Kinetic study revealed that the carboxylate group plays a key role in this system. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：741 / 743

页数：3

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