Class A1 scavenger receptors in cardiovascular diseases

被引：70

作者：

Ben, Jingjing ^{[1
]}

Zhu, Xudong ^{[1
]}

Zhang, Hanwen ^{[1
]}

Chen, Qi ^{[1
]}

机构：

[1] Nanjing Med Univ, Atherosclerosis Res Ctr, Key Lab Cardiovasc Dis & Mol Intervent, Nanjing 210029, Jiangsu, Peoples R China

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2015年 / 172卷 / 23期

基金：

中国国家自然科学基金;

关键词：

LOW-DENSITY-LIPOPROTEIN; NECROSIS-FACTOR-ALPHA; FOAM CELL-FORMATION; MACROPHAGE-SPECIFIC EXPRESSION; MONOCYTE-DERIVED MACROPHAGES; SIGNALING PATHWAYS; SR-A; ATHEROSCLEROTIC LESIONS; CYTOPLASMIC DOMAIN; PROTEIN-KINASE;

D O I：

10.1111/bph.13105

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Class A1 scavenger receptors (SR-A1) are membrane glycoproteins that can form homotrimers. This receptor was originally defined by its ability to mediate the accumulation of lipids in macrophages. Subsequent studies reveal that SR-A1 plays critical roles in innate immunity, cell apoptosis and proliferation. This review highlights recent advances in understanding the structure, receptor pathway and regulation of SR-A1. Although its role in atherosclerosis is disputable, recent discoveries suggest that SR-A1 function in anti-inflammatory responses by promoting an M2 macrophage phenotype in cardiovascular diseases. Therefore, SR-A1 may be a potential target for therapeutic intervention of cardiovascular diseases. Linked ArticlesThis article is part of a themed section on Chinese Innovation in Cardiovascular Drug Discovery. To view the other articles in this section visit http://dx. doi. org/10.1111/bph. 2015.172. issue-23

引用

收藏

页码：5523 / 5530

页数：8

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