Maskless microfabrication of thermosensitive gels using a microscope and application to a controlled release microchip

被引：28

作者：

Yoshida, Ryo ^{[1
]}

Omata, Kazuya ^{[1
]}

Yamaura, Kotaro ^{[1
]}

Ebata, Masaya ^{[1
]}

Tanaka, Masahiro ^{[1
]}

Takai, Madoka ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Engn, Dept Mat Engn, Bunkyo Ku, Tokyo 1138656, Japan

来源：

LAB ON A CHIP | 2006年 / 6卷 / 10期

关键词：

D O I：

10.1039/b606620h

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Here we show a simple and convenient method to prepare micropatterned gels by the use of a microscope, without large-scale or special-order experimental setup. UV light focused by an objective lens was locally irradiated to a pre-gel solution in a microchannel. This method would be useful for preparing microgels at target positions in microchips. A controlled drug-release microchip has actually been fabricated by utilizing this local photo-irradiation method, and pulsatile drug release in response to temperature changes was demonstrated.

引用

页码：1384 / 1386

页数：3

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