Forced Treadmill Running Suppresses Postincisional Pain and Inhibits Upregulation of Substance P and Cytokines in Rat Dorsal Root Ganglion

被引:39
作者
Chen, Yu-Wen [1 ,2 ]
Tzeng, Jann-Inn [3 ,4 ]
Lin, Min-Fei [5 ]
Hung, Ching-Hsia [5 ]
Wang, Jhi-Joung [2 ]
机构
[1] China Med Univ, Grad Inst Rehabil Sci, Dept Phys Therapy, Taichung, Taiwan
[2] Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan
[3] Chi Mei Med Ctr, Dept Anesthesiol, Tainan, Taiwan
[4] Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol, Tainan, Taiwan
[5] Natl Cheng Kung Univ, Inst & Dept Phys Therapy, Tainan 701, Taiwan
关键词
Skin/muscle incision and retraction; mechanical hypersensitivity; forced treadmill running; substance P; interleukin-1; beta; interleukin-6; POSTOPERATIVE PAIN; NEUROPATHIC PAIN; CONTROLLED-TRIAL; SCIATIC-NERVE; EXERCISE; HYPERALGESIA; INFLAMMATION; EXPRESSION; RELEASE; INJURY;
D O I
10.1016/j.jpain.2014.04.010
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
Exercise causes a variety of psychophysical effects (eg, alterations in pain sensation). Tissue injury induces mediator releases in the spinal cord resulting in pain hypersensitivity; however, the contribution of the dorsal root ganglion (DRG) is poorly understood. In this study, we tested if forced treadmill running can attenuate postoperative pain and alter substance P (SP) or proinflammatory cytokine level in the DRG by using a rat model of skin/muscle incision and retraction (SMIR). We evaluated mechanical sensitivity to von Frey stimuli (6 and 15 g) and expression of SP interleukin-1 beta, and interleukin-6 in the DRG of sham-operated sedentary rats, SMIR sedentary rats, sham-operated rats with forced treadmill running, and SMIR rats with forced treadmill running. At postoperative day 8, trained rats ran for 5 days per week for 4 weeks on a treadmill 70 minutes/d with an intensity of 18 m/min. On postoperative day 6, SMIR sedentary rats displayed a significant mechanical hypersensitivity that persisted until postoperative day 35. By comparison, SMIR-operated rats, which received forced treadmill running, exhibited a quick recovery from mechanical hypersensitivity. SMIR sedentary rats showed an upregulation of SP, interleukin-1 beta, and interleukin-6 in the DRG at postoperative days 14 and 28, whereas SMIR-operated rats receiving forced treadmill running reversed this upregulation at postoperative day 28. We concluded that forced treadmill running alleviated persistent postincisional pain caused by SMIR surgery. This appears to be protective against postoperative pain, which probably relates to the downturn in excess SP, interleukin-1 beta, and interleukin-6 in the DRG. Perspective: Controlling the expression of SP, interleukin-6, and interleukin-1 beta in the DRG can help manage postoperative pain. This finding could potentially help clinicians and physical therapists who seek to examine how exercise may attenuate postsurgical pain and its mechanism. (C) 2014 by the American Pain Society
引用
收藏
页码:827 / 834
页数:8
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