α-glucosidase inhibitors from clove (Syzgium aromaticum)

被引：67

作者：

Toda, M ^{[1
]}

Kawabata, J ^{[1
]}

Kasai, T ^{[1
]}

机构：

[1] Hokkaido Univ, Lab Food Biochem, Div Appl Biosci, Res Sch Agr,Kita Ku, Sapporo, Hokkaido 0608589, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2000年 / 64卷 / 02期

关键词：

alpha-glucosidase; inhibitor; clove (Syzgium aromaticum); ellagitannin; Caco-2;

D O I：

10.1271/bbb.64.294

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The ellagitannins, casuarictin and eugeniin, were isolated as rat intestinal maltase inhibitors from Materials and Methods methanol extracts of clove (Syzgium aromaticum). Eugeniin showed inhibitory activity with an IC50 value of 10(-3) m. A structure-activity relationship study among the isolates and their related compound, penta-O-galloyl-beta-D-glucose, indicates that an increasing number of galloyl units in the molecule might lead to an increase in the inhibitory activity. Eugeniin also inhibited maltase activity toward the human intestinal epithelial cell line, Caco-2.

引用

页码：294 / 298

页数：5

共 17 条

[1]

Multiple interactions between polyphenols and a salivary proline-rich protein repeat result in complexation and precipitation [J].