Islet Inflammation in Type 2 Diabetes From metabolic stress to therapy

被引：277

作者：

Donath, Marc Y. ^{[1
]}

Schumann, Desiree M. ^{[1
]}

Faulenbach, Mirjam ^{[1
]}

Ellingsgaard, Helga ^{[1
]}

Perren, Aurei ^{[1
]}

Ehses, Jan A. ^{[1
]}

机构：

[1] Univ Zurich Hosp, Clin Endocrinol & Diabet, Dept Pathol, CH-8091 Zurich, Switzerland

来源：

DIABETES CARE | 2008年 / 31卷

关键词：

D O I：

10.2337/dc08-s243

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Decreases in both mass and secretory function of insulin-producing beta-cells contribute to the pathophysiology of type 2 diabetes. The histology of islets from patients with type 2 diabetes displays an inflammatory process characterized by the presence of cytokines, apoptotic cells, immune cell infiltration, amyloid deposits, and eventually fibrosis. This inflammatory process is probably the combined consequence of dyslipidemia, hyperglycemia, and increased circulating adipokines. Therefore, modulation of intra-islet inflammatory mediators, in particular interleukin-1 beta, appears is a promising therapeutic approach.

引用

页码：S161 / S164

页数：4

共 55 条

[1]

Beneficial effects of insulin versus sulphonylurea on insulin secretion and metabolic control in recently diagnosed type 2 diabetic patients [J].

Alvarsson, M ;

Sundkvist, G ;

Lager, I ;

Henricsson, M ;

Berntorp, K ;

Fernqvist-Forbes, E ;

Steen, L ;

Westermark, G ;

Westermark, P ;

Örn, T ;

Grill, V .

DIABETES CARE, 2003, 26 (08) :2231-2237

[2]

[Anonymous], 1995, Diabetes, V44, P1249

[3]

IL-1 produced and released endogenously within human islets inhibits β cell function [J].

Arnush, M ;

Heitmeier, MR ;

Scarim, AL ;

Marino, MH ;

Manning, PT ;

Corbett, JA .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (03) :516-526

[4]

Elevated plasma leptin concentrations in early stages of experimental intestinal inflammation in rats [J].

Barbier, M ;

Cherbut, C ;

Aubé, AC ;

Blottière, HM ;

Galmiche, JP .

GUT, 1998, 43 (06) :783-790

[5]

Diazoxide treatment at onset preserves residual insulin secretion in adults with autoimmune diabetes [J].

Bjork, E ;

Berne, C ;

Kampe, O ;

Wibell, L ;

Oskarsson, P ;

Karlsson, FA .

DIABETES, 1996, 45 (10) :1427-1430

[6]

BONISCHNETZLER M, 2007, DIABETES S1, V56, pA413

[7]

Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic β-cell function [J].

Busch, AK ;

Cordery, D ;

Denyer, GS ;

Biden, TJ .

DIABETES, 2002, 51 (04) :977-987

[8]

β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes [J].

Butler, AE ;

Janson, J ;

Bonner-Weir, S ;

Ritzel, R ;

Rizza, RA ;

Butler, PC .

DIABETES, 2003, 52 (01) :102-110

[9]

STUDIES IN DIABETIC MUTANT MOUSE .3. PHYSIOLOGICAL FACTORS ASSOCIATED WITH ALTERATIONS IN BETA CELL PROLIFERATION [J].

CHICK, WL ;

LIKE, AA .

DIABETOLOGIA, 1970, 6 (03) :243-+

[10]

Low density lipoprotein can cause death of islet β-cells by its cellular uptake and oxidative modification [J].

Cnop, M ;

Hannaert, JC ;

Grupping, AY ;

Pipeleers, DG .

ENDOCRINOLOGY, 2002, 143 (09) :3449-3453

← 1 2 3 4 5 6 →