Effect of soluble fiber intake in lipid and glucose leves in healthy subjects: a randomized clinical trial

被引:60
作者
Aller, R
de Luis, DA
Izaola, O
La Calle, F
del Olmo, L
Fernandez, L
Arranz, T
Hernandez, JMG
机构
[1] Univ Valladolid, Sch Med, Inst Endocrinol & Nutr, Valladolid 47130, Spain
[2] Univ Valladolid, Hosp Rio Hortega, Valladolid 47130, Spain
关键词
intake; healthy subjects; soluble fiber;
D O I
10.1016/j.diabres.2003.11.005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: The aim of our work was to carry out a randomized clinical trial with two diets, one enriched in fiber (total fiber 30 g and soluble fiber 4 g) to investigate the effect on lipid and glucose levels in healthy subjects. Research design and methods: Fifty-three subjects were prospectively randomized to two groups (see Table 1). Group I received a diet with 10.4 g of fiber given as 1.97 g soluble fiber (pectins, gums and mucilages) and 8.13 g of insoluble fiber (hemicelullose, cellulose and lignins) and Group II received a diet with 30.5 g of fiber of which 4.11 g were soluble fiber and 25.08 g insoluble fiber. Prospective serial assessment of weight and nutritional intake (3 days written food records) were made. These determinations were performed at baseline and at 3 months. All enrolled subjects underwent the following examinations; fasting blood samples were drawn for measurement of total cholesterol, triglyceride concentrations and other lipid fractions, low density lipoprotein (LDL-cholesterol), high density lipoprotein (HDL-cholesterol), glucose, and insulin. Results: Total calorie and fat consumption were lower than recommended in both groups (calories; group I 1633 +/- 417 kcal per day versus group II 1707.5 +/- 579 kcal per day:ns) and (fats; group I 73.4 +/- 22.7 g per day versus group II 72.6 +/- 28 g per day:ns), without differences in fatty acid intake profile. Total fiber intake did not reach that recommended in both diets but it was higher in group II (9.06 +/- 2.7 g per day versus 25.95 +/- 7.12 g per day: P < 0.05). Soluble fiber intake did not reach that recommended in both diets but it was higher in group II (1.7 +/- 0.58 g per day versus 3.5 +/- 0.96 g per day: P < 0.05). Body weight did not change in both groups during treatment. During treatment, in group II a significant change was detected from baseline in LDL-cholesterol and fasting glucose levels. LDL-cholesterol decreased by 12.8% (P < 0.05) and glucose decreased by 12.3% (P < 0.05). No statistical differences were detected among triglycerides, HDL-cholesterol, and insulin levels. Conclusions: Modest increases in soluble fiber intake in healthy subjects improved LDL cholesterol and glucose levels. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:7 / 11
页数:5
相关论文
共 15 条
  • [1] ANDERSON JW, 1986, AM J GASTROENTEROL, V81, P907
  • [2] Brown L, 1999, AM J CLIN NUTR, V69, P30
  • [3] Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus
    Chandalia, M
    Garg, A
    Lutjohann, D
    von Bergmann, K
    Grundy, SM
    Brinkley, LJ
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (19) : 1392 - 1398
  • [4] Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
    Cleeman, JI
    Grundy, SM
    Becker, D
    Clark, LT
    Cooper, RS
    Denke, MA
    Howard, WJ
    Hunninghake, DB
    Illingworth, DR
    Luepker, RV
    McBride, P
    McKenney, JM
    Pasternak, RC
    Stone, NJ
    Van Horn, L
    Brewer, HB
    Ernst, ND
    Gordon, D
    Levy, D
    Rifkind, B
    Rossouw, JE
    Savage, P
    Haffner, SM
    Orloff, DG
    Proschan, MA
    Schwartz, JS
    Sempos, CT
    Shero, ST
    Murray, EZ
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19): : 2486 - 2497
  • [5] Connor WE, 1997, NEW ENGL J MED, V337, P562
  • [6] SERUM CHOLESTEROL, LIPOPROTEINS, AND RISK OF CORONARY HEART DISEASE - FRAMINGHAM STUDY
    KANNEL, WB
    CASTELLI, WP
    GORDON, T
    MCNAMARA, PM
    [J]. ANNALS OF INTERNAL MEDICINE, 1971, 74 (01) : 1 - +
  • [7] MATAIX J, 1998, TABLAS COMP ALIM ESP
  • [8] THE EFFECTS OF DIETARY FIBER FEEDING ON CHOLESTEROL-METABOLISM IN RATS
    NISHINA, PM
    FREEDLAND, RA
    [J]. JOURNAL OF NUTRITION, 1990, 120 (07) : 800 - 805
  • [9] African plant foods rich in non-starch polysaccharides reduce postprandial blood glucose and insulin concentrations in healthy human subjects
    Onyechi, UA
    Judd, PA
    Ellis, PR
    [J]. BRITISH JOURNAL OF NUTRITION, 1998, 80 (05) : 419 - 428
  • [10] Parks EJ, 2000, AM J CLIN NUTR, V71, P412