NAADP: An emerging calcium signaling molecule

被引：40

作者：

Lee, HC ^{[1
]}

机构：

[1] Univ Minnesota, Dept Pharmacol, Minneapolis, MN 55455 USA

来源：

JOURNAL OF MEMBRANE BIOLOGY | 2000年 / 173卷 / 01期

关键词：

NAADP; cyclic ADP-ribose; calcium stores; calcium signaling; ADP-ribosyl cyclase; CD38;

D O I：

10.1007/s002320001001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cells possess multiple Ca2+ stores and multiple messengers for mobilizing them. In addition to inositol trisphosphate and cyclic ADP-ribose, nicotinic acid adenine dinucleotide phosphate (NAADP), a metabolite of NADP, is shown to be a potent Ca2+ signaling molecule in both invertebrate and mammalian cells. This article summarizes the recent results of this newly discovered Ca2+ signaling mechanism and explores the implications of the apparent proliferation of Ca2+ messengers.

引用

页码：1 / 8

页数：8

共 86 条

[1] Activation and inactivation of Ca2+ release by NAADP(+) [J].

Aarhus, R ;

Dickey, DM ;

Graeff, RM ;

Gee, KR ;

Walseth, TF ;

Lee, HC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (15) :8513-8516

[2] ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADP(+) [J].

Aarhus, R ;

Graeff, RM ;

Dickey, DM ;

Walseth, TF ;

Lee, HC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (51) :30327-30333

[3] The two intracellular Ca2+ release channels, ryanodine receptor and inositol 1,4,5-trisphosphate receptor, play different roles during fertilization in ascidians [J].

Albrieux, M ;

Sardet, C ;

Villaz, M .

DEVELOPMENTAL BIOLOGY, 1997, 189 (02) :174-185

[4] Calcium signaling by cyclic ADP-ribose, NAADP, and inositol trisphosphate are involved in distinct functions in ascidian oocytes [J].

Albrieux, M ;

Lee, HC ;

Villaz, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (23) :14566-14574

[5] RANGE OF MESSENGER ACTION OF CALCIUM-ION AND INOSITOL 1,4,5-TRISPHOSPHATE [J].

ALLBRITTON, NL ;

MEYER, T ;

STRYER, L .

SCIENCE, 1992, 258 (5089) :1812-1815

[6]

AYABE T, 1995, DEVELOPMENT, V121, P2233

[7] Nicotinic acid adenine dinucleotide phosphate triggers Ca2+ release from brain microsomes [J].

Bak, J ;

White, P ;

Timár, G ;

Missiaen, L ;

Genazzani, AA ;

Galione, A .

CURRENT BIOLOGY, 1999, 9 (14) :751-754

[8] INOSITOL TRISPHOSPHATE AND CALCIUM SIGNALING [J].

BERRIDGE, MJ .

NATURE, 1993, 361 (6410) :315-325

[9]

BERRIDGE MJ, 1997, NATURE, V386, P769

[10] BELL-SHAPED CALCIUM-RESPONSE CURVES OF INS(1,4,5)P3-GATED AND CALCIUM-GATED CHANNELS FROM ENDOPLASMIC-RETICULUM OF CEREBELLUM [J].

BEZPROZVANNY, I ;

WATRAS, J ;

EHRLICH, BE .

NATURE, 1991, 351 (6329) :751-754

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