The physiological significance of mitochondrial proton leak in animal cells and tissues

被引：210

作者：

Rolfe, DFS ^{[1
]}

Brand, MD ^{[1
]}

机构：

[1] UNIV CAMBRIDGE, DEPT BIOCHEM, CAMBRIDGE CB2 1QW, ENGLAND

来源：

BIOSCIENCE REPORTS | 1997年 / 17卷 / 01期

关键词：

mitochondria; proton leak; Standard Metabolic Rate; thermogenesis; metabolic sensitivity; reactive oxygen species; carbon flux control;

D O I：

10.1023/A:1027327015957

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Mitochondrial proton leak is an important component of cellular metabolism in animals and may account for as much as one quarter to one third of the Standard Metabolic Rate of the rat. The activity of the proton leak pathway is different in a wide range of animal species and in different thyroid states. Such differences imply some function for proton leak and candidates for this function include thermogenesis, protection against reactive oxygen species, endowment of metabolic sensitivity and maintenance of carbon fluxes.

引用

页码：9 / 16

页数：8

共 36 条

[1]

AMBROSIO G, 1993, J BIOL CHEM, V268, P18532

[2]

Berry M.N., 1991, Isolated hepatocytes. Properties, V1st edition

[3]

EVOLUTION OF ENERGY-METABOLISM - PROTON PERMEABILITY OF THE INNER MEMBRANE OF LIVER-MITOCHONDRIA IS GREATER IN A MAMMAL THAN IN A REPTILE [J].