Mycobacterium tuberculosis malate synthase- and MPT51-based serodiagnostic assay as an adjunct to rapid identification of pulmonary tuberculosis

被引：29

作者：

Achkar, Jacqueline M.

Dong, Yuxin

Holzman, Robert S.

Belisle, John

Kourbeti, Irene S.

Sherpa, Tsering

Condos, Rany

Rom, William N.

Laal, Suman

机构：

[1] NYU, Sch Med, New York, NY 10016 USA

[2] New York Harbor Hlth Care Syst, Dept Vet Affairs, New York, NY 10010 USA

[3] Colorado State Univ, Dept Micbiol Immunol & Pathol, Ft Collins, CO 80523 USA

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2006年 / 13卷 / 11期

关键词：

D O I：

10.1128/CVI.00158-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The 81-kDa malate synthase (MS; Rv 1837c) and the 27-kDa MPT51 (Rv 3803c) of Mycobacterium tuberculosis are immunodominant antigens recognized by serum antibodies from similar to 80% of human immunodeficiency virus-negative smear-positive tuberculosis patients from India. We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis.

引用

页码：1291 / 1293

页数：3

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