Clinical Outlook for Type-1 and FOXP3+ T Regulatory Cell-Based Therapy

被引：50

作者：

Gregori, Silvia ^{[1
]}

Passerini, Laura ^{[1
]}

Roncarolo, Maria-Grazia ^{[2
]}

机构：

[1] San Raffaele Telethon Inst Gene Therapy TIGET, IRCCS San Raffaele Sci Inst, Div Regenerat Med Stem Cells & Gene Therapy, Milan, Italy

[2] Stanford Sch Med, Dept Pediat Stem Cell Transplantat & Regenerat Me, Palo Alto, CA USA

来源：

FRONTIERS IN IMMUNOLOGY | 2015年 / 6卷

关键词：

T regulatory cells; T regulatory type 1 cells; tolerance; Treg-based therapy; IL-10; FOXP3; gene transfer; LATENT TGF-BETA; PERIPHERAL-BLOOD; IMMUNE-RESPONSES; TR1; CELLS; EXPRESSION; TRANSPLANTATION; EXPANSION; SUPPRESSION; TOLERANCE; RAPAMYCIN;

D O I：

10.3389/fimmu.2015.00593

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

T regulatory cells (Tregs) are subsets of T lymphocytes specialized in modulating antigen-specific immune responses in vivo. Hence, Tregs represent an ideal therapeutic tool to control detrimental immune reactions. Based on solid pre-clinical results, investigators started testing the safety and efficacy of Treg-based therapies in humans. Despite promising results, a number of issues remain to be solved. We will discuss the results obtained from clinical trials and the challenges and risks we are facing in the further development of Treg-based therapies.

引用

页数：8

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