A potential set up based on histidine hollow fiber membranes for the extracorporeal removal of human antibodies

被引：35

作者：

Pitiot, O ^{[1
]}

Legallais, C ^{[1
]}

Darnige, L ^{[1
]}

Vijayalakshmi, MA ^{[1
]}

机构：

[1] Univ Technol Compiegne, LIMTechS, CNRS, UPRES A 6 022,Ctr Rech Royallieu, F-60205 Compiegne, France

来源：

JOURNAL OF MEMBRANE SCIENCE | 2000年 / 166卷 / 02期

关键词：

histidine; membrane affinity chromatography; hollow fiber membranes; immunoglobulins; autoimmune antibodies; extracorporeal removal;

D O I：

10.1016/S0376-7388(99)00260-4

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Poly ethylene vinyl alcohol (PEVA) based hollow fiber membrane grafted with L-histidine has been found to be particularly useful for the preparative scale separation of immunoglobulin G and potential clinical applications. In this paper, we present a set-up designed for the extracorporeal removal of immunoglobulin G. Biochemical and hydrodynamic conditions were optimized so as to perform in vitro removal of 50% of plasma immunoglobulin G. (C) 2000 Elsevier Science B.V. All rights reserved.

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页码：221 / 227

页数：7

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